Sanford is a city and the county seat of Seminole County, Florida, United States. It is located in Central Florida and its population was 61,051 a…Sanford is a city and the county seat of Seminole County, Florida, United States. It is located in Central Florida and its population was 61,051 as of the 2020 census. It is part of the Orlando–Kissimmee–Sanford Metropolitan Statistical Area.
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