Sanford is a city in Lee County, North Carolina, United States. The population was 30,261 at the 2020 census. It is the county seat of Le…Sanford is a city in Lee County, North Carolina, United States. The population was 30,261 at the 2020 census. It is the county seat of Lee County. The geographic center of North Carolina is located northwest of the city, in Chatham County.
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