Detroit Lions head to San Fran on a mission towards clinching the #1 seed in the NFC. Check out our best bet and any player news.

To make matters worse, offensive lineman Spencer Burford, who was supposed to start at left tackle with Williams and his backup Jaylon Moore on IR for the season, is listed as ‘out’ on the injury report with a calf injury he sustained in the team’s Week 16 loss to the Miami Dolphins.

The bad injury situation exacerbated for the 49ers during the week with multiple downgrades – Colton McKivitz, Charvarius Ward, and Ji’Ayir Brown. Two of those are starting secondary players which would hamper the 49er pass defense. Meanwhile, the Lions got an upgrade with Terrion Arnold.