PsyPost on MSN1d
Scientists uncover delayed effects of citalopram on brain’s reward system
A new study on mice reveals that the brain’s response to rewards is temporarily suppressed after the first dose of citalopram ...
Chip Chick on MSN9mon
The Colorado River Toad Secretes A Potent Poison That Has Psychedelic Properties And May Be Helpful In Treating Anxiety And Depression
The researchers extracted the poison from the toad’s secretions and used mice to see how it would interact with a serotonin ...
pharmaphorum20h
Exscientia starts trials of AI-designed Alzheimer's drug
According to the partners, DSP-0038 combines serotonin 5-HT2A receptor antagonism and 5-HT1A receptor agonism – two well established targets for antipsychotic drugs – in a single small molecule.
Nature4y
Focusing on women: creating new solutions for sexual dysfunction
In these women, sublingual testosterone can increase sensitivity to sexual stimuli, and a subsequent dose of a 5-HT1A-receptor agonist then inhibits the sexual-inhibition mechanism. On the basis ...
pharmaphorum22d
Exscientia claims world first as AI-created drug enters clinic
The drug is a long-acting and potent serotonin 5-HT1A receptor agonist and will be added to DSP’s psychiatry and neurology research pipeline. Paul Workman, chief executive of The Institute of ...
Seeking Alpha3d
AXSM Axsome Therapeutics, Inc.
trace amine-associated receptor 1 agonist, and 5-HT1A agonist indicated for the treatment of excessive daytime sleepiness in patients with narcolepsy or obstructive sleep apnea; and Symbravo ...
Concordia University1y
Matthew Gardner
Si YG, Gardner MP, Tarazi FI, Baldessarini RJ, Neumeyer JL (2007). R-(-)-N-alkyl-11-hydroxy-10-hydroxymethyl- and 10-methyl-aporphines as 5-HT1A receptor ligands. Bioorg Med Chem Lett 17:4128-4130.