The SuM. Injection of Cre-dependent AAV in SuM-Cre mice resulted in SuM-restricted eYFP (green) expression and strong terminal labeling in the DG and CA2 of the hippocampus. Scale bar, 1 mm ...

There is a growing list of approved AAV-based gene therapies and hundreds more in the clinical ... To specifically select for viruses that successfully traversed the BBB, Deverman injected Cre ...

For central nervous system (CNS) applications, attempts are being made to deliver AAV gene therapy directly to the brain parenchyma or the cerebrospinal fluid (CSF) space by intra-cisterna magna ...

Viral vectors expressing proneural genes can stimulate adult mammalian retinal glia to become immature neurons. These glia-derived neurons share properties with the bipolar, amacrine and retinal ...

Somatic gene transfer with vectors such as adeno-associated virus (AAV) can overcome these limitations. ReGenX's AAV Vector Technology gives extremely efficient and stable gene expression in ...