May cause severe bone marrow suppression with resulting infection ... and of concomitant disease or other drug therapy. Mean (±SD) peak melphalan plasma concentrations in myeloma patients given ...

The most important toxicity that threatens the survival of the patient is bone marrow suppression ... In addition, drugs that target growing cells interfere with gut epithelial renewal and ...

Ischemic cardiac disease. Bone marrow suppression; monitor WBC before and during treatment. Avoid contamination of the eyes or injecting into an extremity with poor circulation (thrombosis possible).