Scientists at the Faculty of Medicine at the University of Freiburg have now shown that a sudden stop in energy production in mitochondria prevents normal cell death or so-called apoptosis and ...

can stimulate both apoptosis and autophagy. Organellar stress that affects mitochondria and the endoplasmic reticulum can induce a specific autophagic response that leads to the removal of damaged ...

Our findings demonstrate that mitochondria dynamics do not regulate apoptosis activation in C. elegans and reveal distinct roles for drp-1 and fis-2 as mediators of cell-death execution downstream of ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes ...

In Ming-Chiu Fung’s immunology lab, Hogan had been investigating how disturbances in the cytoskeletons of cells might contribute to the fragmentation of mitochondria during apoptosis, the most ...

By around 2000, apoptosis had become the prominent mode ... of intrinsic hepatotoxins have revealed oxidative stress and mitochondrial dysfunction as key contributors to injury.