Autophagy is the process by which cells digest and renew their internal structures, recycling damaged or malfunctioning ...
Headed by Drs. Antonio Zorzano and Saska Ivanova, a study published in the journal Autophagy unravels the relationship between mitofusins (mitochondrial proteins) and autophagy. Using gene editing ...
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Powering brain health: How autophagy protects neurons by controlling their glucose consumption"Our research demonstrates that autophagy isn't just about clearing damaged mitochondria or protein aggregates," explained first author Dr. Janine Tutas. "In Purkinje cells, ATG5 actively ...
We are driven to understand the signals regulating tissue-specific autophagy signalling in mammalian health and disease. Understanding the physiological regulation and significance of selective ...
A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...
Autophagy loss increases PC vulnerability, independent of its role in protein and mitochondria quality control. Credit: Nature Metabolism (2025). DOI: 10.1038/s42255-024-01196-4 ...
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