Tumor-suppressor genes that many people are familiar with are the BRCA genes. BRCA gene mutations are known to be associated with the development of breast cancer and other tumors. TP53 is a ...

These findings provide evidence that promoter methylation of Dkk-3 is a common event in gastric cancer and that Dkk-3 is a tumor suppressor gene through the inhibition of Wnt signaling.

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body’s immune response ...

Table 2. Associations of brown fat, obesity and loss/mutation of tumor suppressor genes in endometrial and breast cancer. † P53 mutation in case of PTEN or BRCA1 mutation. ‡ Brown fat state in ...

Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

A study published in Science Advances reveals a novel strategy that allows tumors to evade the body's immune response ...

The breakthrough stems from a discovery by UK College of Medicine professor of radiation medicine Vivek Rangnekar and a team of researchers who found a tumor-suppressor gene called "Par-4" in the ...

The construction of the bridges causes these cells to produce a small protein that is known as a key suppressor of the immune response. When this protein is expressed in the tumor microenvironment ...

A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, ...

Ten years later, it changed from an oncogene to a tumor suppressor gene. And that just changed the ... Huang and his group study p53 gain-of-function in breast cancer models to identify mutant p53 ...

A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, according to new research led by investigators at the Johns Hopkins Kimmel ...