An "unbiased" screen for genes involved in opioid tolerance relied upon tiny worms called C. elegans. The worm genetics revealed PTCHD1 plays a key role, altering cholesterol in cell membranes.
The team examined live embryos of C. elegans using two instruments invented at the MBL: the centrifuge polarizing microscope ...
Scientists built a microfluidic lab-on-a-chip device that accelerates compound screens and phenotype analyses in C. elegans models of reproductive aging. Deanna earned their PhD in cellular biology ...
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