Chromosomal translocations occur in leukemias, lymphomas, sarcomas and some epithelial tumors and some generate unique fusion proteins. These translocation products may provide tumor-specific ...

Translocations generate novel chromosomes, but are often linked to disorders like infertility and cancer. How do these new chromosomes generate problems, and how are they detected? Translocations ...

It is a genetic condition caused when an unusual cell division result in an extra full or even partial copy of chromosome 21. This extra genetic material causes the developmental changes and physical ...

A century after Down syndrome was first described, scientists discovered that the root cause of this disorder is a condition called trisomy 21. What strides in research have been made since then?

Professor Terry Rabbitts’ research is focussed on new strategies using intracellular antibodies and derivates for therapy aimed at hard-to-drug chromosomal translocation gene products. Our research is ...

The remaining recombinants transferred a larger amount of sequence information, but in no instances were translocations or other genome rearrangements observed. Richardson C, Jasin M. 2000 Frequent ...

Down syndrome is a common chromosomal disorder caused by an extra chromosome 21, leading to intellectual disabilities and distinct physical traits. Early diagnosis and therapies significantly improve ...

All array platforms will detect copy number variations including deletions, duplications, unbalanced translocations, some marker chromosomes and aneuploidy. SNP arrays have the added advantage of ...

Dr. Gregory Bean, Associate Professor of Pathology at Stanford University, will describe the direct detection of mRNA from CRTC1/3::MAML2 translocations, as alternatives to MAML2 FISH, in the ...

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