The neuronal accumulation of mutant huntingtin is a hallmark of Huntington's disease. New research shows that post-translational modifications of the mutant protein promote its clearance ...

They include the dysregulation of the expression of thousands of genes in the striatal neurons and an accumulation of clumps of mutant Huntingtin protein (called aggregates), which are a hallmark of ...

HD is caused by an expanded glutamine repeat in the N-terminal region of the huntingtin (HTT) protein ... High expression of the mutant HTT is significantly correlated with the downregulation of the ...