For all six proteins, three 'loop' regions are most important for sequence specific DNA binding. The first of these is a segment between the first two strands of the Ig-fold, referred to as the A ...

C2H2 zinc finger proteins are the largest group of DNA-binding factors for transcription—the process of copying genetic information from DNA to messenger RNA (mRNA). As there are more than 700 ...

Fritz Lipmann Institute (FLI) in Jena have discovered a new function of the DNA repair protein ATR in regulating ...

Accumulation of a protein called TDP-43 is a key feature of ALS and frontotemporal dementia. In a newly published study, ...

Mobile DNA elements, such as Insertion Sequence (IS) elements, transposons, integrative elements (e.g. integrative islands), ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For ...

Discover how scientists captured the action of helicases in DNA replication, revealing crucial insights into this fundamental process.

The University of Arkansas for Medical Sciences (UAMS) researcher Kevin Raney, Ph.D., has been awarded a five-year, $2.99 ...

Transcription factors are proteins that act as ‘master switches’ of gene ... the target and won’t let go – it grips the cJun tightly and stops it from binding to the DNA. “We’d previously identified ...

The DNA vaccine-derived protein antigen (3 ... Peptide antigen/MHC I complexes are presented on the cell surface (6), binding cytotoxic CD 8+ lymphocytes, and inducing a cell-mediated immune ...