Mitochondria are well known as the powerhouses of the cell. These crucial, energy generating organelles even have their own little genomes... | Cell And Molecular Biology ...

Similarly, a homoplasmic mutation in a mitochondrial genome-encoded ribosomal RNA, called RNR1, causes postlingual deafness ... The clinical symptoms of this disease are associated with the ...

Mitochondria play a crucial role in cellular energy production, and their dysfunction has long been linked to metabolic ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death. Mitochondrial Ca2+ (Ca2+mito) plays a dual role in physiological processes ...

Mitochondria are central to energy production in cells, and their dysfunction is increasingly implicated in the aging process and the pathogenesis of ...

Thus, mitochondrial dysfunction caused by ΔmtDNA4696 resulted in expression of disease phenotypes which corresponded to those in human subjects with predominantly ΔmtDNA (refs. 11–15).

However, in AD, mitochondrial dysfunction leads to ... providing a new direction for developing treatments that address the disease's root causes. Dr. Jian Sima, senior author of the study ...

Mitochondrial defects, however, are associated with the development of diseases such as type 2 diabetes. Patients who suffer from this disorder are unable to produce enough insulin or use the insulin ...

Mitochondria are essential for generating energy that fuels cells and helps them function. Mitochondrial defects, however, ...

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...