The ligand is expressed for the lifespan of the ... important in the successful targeting of solid tumors. In addition, DR5 TRAIL variant expressing NK cells may also be less susceptible to ...
These results clearly demonstrate significant biological differences among these three recombinant ligand preparations. It seems that use of NT-Apo2L/TRAIL might be the preferred death ligand ...
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis of tumor cells but not most normal cells. Its roles in normal nontransformed tissues are not clear.