This historical perspective integrates 50 years of research on SOS mutagenesis in Escherichia coli with the proverbial ... recombination—that feature DNA polymerase V. Genetic and biochemical ...

More information: Sofya K Garushyants et al, Mutational Signatures in Wild Type Escherichia coli Strains Reveal Predominance ...

This important study presents compelling observational data supporting a role for transcription and polysome accumulation in the separation of newly replicated bacterial chromosomes. The study is ...

They were particularly drawn to features of T7 DNA polymerase—derived from the T7 bacteriophage that infects Escherichia coli—due to its ability to synthesize long stretches of DNA by binding and ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli ... the RNA polymerase (RNAP) enzyme responsible for copying DNA into RNA can generate rampant R-loops ...

Erlich led the team of scientists at the Cetus Corporation that developed the PCR method. In the 1950s, scientists discovered Escherichia coli DNA polymerase and immediately put it to use synthesizing ...

How cells respond to mitochondrial DNA (mtDNA) damage is not fully understood. This study uncovers a mechanism of mtDNA ...

As DNA polymerase makes its way down the unwound ... In the prokaryotic bacterium E. coli, replication can occur at a rate of 1,000 nucleotides per second. In comparison, eukaryotic human DNA ...

The findings demonstrate that, under certain circumstances, the RNA polymerase (RNAP) enzyme responsible for copying DNA into RNA can ... group found that E. coli exposed to stressful, high ...