The different positions and movements of the extracellular region appear to be an important way to activate the receptor. "This opens up new opportunities for drugging adhesion GPCRs, because now ...

For example, membrane receptors bind and respond to specific molecules outside the cell, such as hormones, neurotransmitters, the extracellular matrix, and attachment molecules on other cells.

ionophores, calcium chelators, as well as ligands for intracellular and extracellular receptors. "We had found a gene and the GPCR it encoded, ...

Receptors are shown as two lobes connected by a transmembrane stretch. Binding of a ligand, neuregulin (NRG, blue square) or something EGF-like to the extracellular lobe activates the receptors.

Initiation of Phase 1/2 combination trial with PYX-201, an extracellular ADC targeting Extradomain-B Fibronectin (EDB+FN) and ...

An approach using engineered small extracellular vesicles from NK cells to DR5 could be a promising strategy for solid tumors.

Recently, it has become clear that glycosylation as well as other posttranslational events play a crucial role in the temporal and spatial regulation of signal transmission by altering extracellular ...

Scientists from the University of Pennsylvania have developed an innovative cancer treatment using small extracellular ...

Researchers at Penn Medicine created an innovative cancer treatment using nano-sized capsules that can target and trigger cancer cell self-destruction.

Explore the role of the extracellular matrix (ECM) in prostate cancer progression and discover natural therapies, including ...

The DR5 death receptor appears to have evolved ... Xu and his team used extracellular vesicles to target DR5 because these nano-sized capsules—about a million times smaller than a T cell ...