because immortalized glomerular human endothelial cells did not respond to insulin. In podocytes, as in muscle and adipocytes, GLUT4 translocation is dependent on an intact actin cytoskeleton to ...

The glomerular filtration barrier, from the blood to the urinary space, consists of endothelial cells, a basement membrane and specialized epithelial cells called podocytes. Endothelial cells have ...

Injury of podocytes, if recognized at all ... TGF-β1 causes an increase in mesangial matrix deposition and glomerular basement membrane (GBM) thickening and may promote podocyte apoptosis ...

Filtration is dependent on the unique structure of the capillary wall comprising layers of two key cells types, glomerular endothelial cells (GEnC) and podocytes, separated by a specialised basement ...

Podocytes are highly specialised, terminally differentiated cells with a complex cellular architecture. They are a critical component of glomerular filtration. Cell-cycle control, growth arrest and ...

Glomerular diseases encompass a wide spectrum ... Here the authors report that ceramide synthase 6 (CerS6) in podocytes contributes to the pathogenesis of diabetic kidney disease (DKD) in male ...