In a study published in Cell, a research team led by Zhu Shujia from the Center for Excellence in Brain Science and ...

AMPA receptors, ligand-gated ion channels that mediate fast, excitatory synaptic transmissions, are activated by glutamate, the primary neurotransmitter of the mammalian brain. Surprisingly ...

Pathologically high levels of extracellular glutamate can cause excitotoxicity, when postsynaptic receptors such as NMDA and AMPA are overactivated, allowing high levels of calcium influx that trigger ...

So far, we have identified several novel features related to functions and regulation of AMPA and kainate-type glutamate receptors at the developing synapses. Our current research aims to understand ...

Perampanel is a non-competitive antagonist of the ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor on post-synaptic neurons. Glutamate is the primary ...