The principal (i.e dominant) nodule(s) in a multinodular goiter should be biopsied using ultrasound guidance.

Generalized enlargement of the thyroid gland (goiter) due to iodine deficiency is ... is functioning normally or abnormally. Imaging (CT or ultrasound) will allow physicians to evaluate the size of ...

Elastography or ultrasound ... thyroid gland size and the amount of thyroid hormone it produces. This therapy can be used to treat a single toxic nodule or toxic multinodular goiter.