Why anti-TNF drugs don't work for some kids with Crohn's disease
A study by Michigan Medicine researchers has investigated possible genetic factors for drug efficacy for children with ...
Medscape2d
Trends in HLA Antibody Screening and Identification and Their Role in Transplantation
HLA testing has been a staple in transplantation since the recognition that antibodies, directed against lymphocytes, were associated with allograft failure. This seminal finding led to the ...
Nature8y
HLA-DPB1 mismatch alleles represent powerful leukemia rejection antigens in CD4 T-cell immunotherapy after allogeneic stem-cell transplantation
Refractory or relapsed acute myeloid leukemia (AML) represents a frequent complication after allogeneic hematopoietic stem-cell transplantation (HSCT). We show herein that primary in vitro ...
Medscape3d
Primer: Immunity and Autoimmunity
The genes that encode class I MHC consist of HLA-A, -B, and -C, whereas class II molecules are encoded by the DR, DQ, and DP genes. Aly et al. [17] provided evidence that risk for islet ...