Basically, they increase the pain you feel. NSAIDs work on a chemical level. They block the effects of special enzymes -- specifically Cox-1 and Cox-2 enzymes. These enzymes play a key role in ...

NSAIDs work to reduce pain by blocking the enzymes that are involved in the production of certain prostaglandins. Prostaglandins are also protective in the mucosal layer of the stomach ...

Conclusions: Short-term evaluation indicates that oral enzymes may be considered an effective and safe alternative to NSAIDs such as diclofenac in the treatment of painful gonarthritis.

How enzyme supplements work is that they regulate the inflammatory ... of gastrointestinal side effects is very low compared with NSAIDs. Always ask your doctor first before taking any enzyme ...