developmental pathways disrupted in IBD and the role of tyrosine phosphatases in disease pathogenesis. Brief summaries of other implicated genes are provided in Box 3. Perhaps the most exciting ...

The most widely held hypothesis on the pathogenesis of IBD is that overly aggressive acquired (T cell) immune responses to a subset of commensal enteric bacteria develop in genetically susceptible ...

Thus, focusing on the ability of this model to portray UC pathophysiology, the research team next tested the effects of a commonly used drug for treating UC, tofacitinib, in IBD-like colonic ...