Mammalian AMP-activated protein kinase (AMPK) was discovered as a protein ... to AMP and pyrophosphate). If the latter reactions were allowed to reach equilibrium, cells would become ...

Researchers have unveiled a novel immune mechanism by which tandem kinases combat pathogen invasion: an atypical NLR protein, ...

Using genetically predicted metabolic reaction fluxes, the authors identify reactions that can amplify or buffer the effect ...

RNA cleavage can occur either: (i) by a transesterification mechanism that yields 2’,3’-cyclic-PO ... all strongly prefer GTP as the NTP phosphate donor for their 5’ kinase reactions. We recently ...

The challenge is understanding the specific molecular reactions that lead to the plant ... freeing the other kinase to switch on the immune response. This mechanism had never been previously observed ...

especially the mechanisms by which transmembrane receptors bind specific attractants and regulate the output kinase activity. This kinase activity controls the swimming motor and cellular migration up ...

The assay is run in two main steps, the kinase reaction step followed by the detection step with HTRF reagents (Fig. 1). The phosphorylation of the biotin-tagged generic peptide is initiated by ...

A research team led by Prof. LIU Zhiyong from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, together with collaborators, has uncovered a novel immune ...