Knockdown is typically observed 24–48 h after transfection and can be even more rapid using siRNA (in comparison with shRNA). Because protein half-lives can vary, interrogation of mRNA levels ...

this construct was shown to facilitate siRNA-mediated gene knockdown in neuronal cells, in contrast to a control construct engineered with a peptide derived from the rabies virus matrix protein.

Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.

The company has already kicked off an open-label Phase I trial of ABX1100 in Canada following positive results from a study of healthy volunteers.

The investigators observed approximately 70% knockdown of GYS1 mRNA and protein at 10 weeks following ... from the bench to bedside for our Centyrin-siRNA platform.” ABX1100 was well-tolerated ...

RNA interference, or RNAi, is all the rage these days. According to the Web of Science database (ISI, Philadelphia), the number of articles on the topic jumped from nine in 1998 to 229 in 2002. Why ...

More information: Shireesha Manturthi et al, Nanoparticles Codelivering mRNA and SiRNA for Simultaneous Restoration and Silencing of Gene/Protein Expression In Vitro and In Vivo, ACS Nanoscience ...

ADA2, a secreted protein with lower catalytic activity ... including cell isolation and culture, knock-down of ADA2 expression with siRNA, immunostaining, and confocal microscopy, to demonstrate ...

Announcement coincides with WORLDSymposium™ presentation highlighting knockdown of GYS1 mRNA and protein in muscle ... deliver a short-interfering RNA (siRNA) therapeutic payload directly ...