Both Setd2-CD and Setd2-KO mice exhibited embryonic lethality ... the generation of point mutation CD knockin animal models and direct comparison with KO models is considered an objective standard ...

including null or point mutations and complex chromosomal rearrangements such as large deletions, translocations, or inversions (Bedell et al., 1997a). Many knock-out and knock-in mice have ...

People with certain mutations in the gene coding for dysferlin ... edit them and transplant the corrected cells back into mice, where protein function was restored and muscles began to regrow.