E3-ubiquitin ligase inducible degrader of the LDL receptor has a similar function to PCSK9 and is a potential therapeutic target. A desirable treatment target for HoFH patients is LDL-C ≤1.8 mmol/l.

Your best treatment option for high cholesterol depends ... It determines the number of low-density lipoprotein (LDL) receptors in the body. These receptors then regulate how much LDL cholesterol ...

A cholesterol receptor protein called LDLR appears to be a key driver of neurotoxicity in sporadic ALS, per new research ...

However, the diterpene compounds seem to impact how much LDL receptors in cells are able to process circulating LDL in the body, he says. Diterpenes also seem to suppress enzymes linked to the ...

The three key mutations are in the gene for the LDL cholesterol receptor that is supposed to ... help determine your future risk, inform your treatment, and allow family members to be checked ...

Once processed by LPL, the VLDL becomes a VLDL remnant. The majority of the VLDL remnants are taken up by the liver via the LDL receptor, and the remaining remnant particles become IDL ...

LDL is often called “bad” cholesterol because when it accumulates in the blood, it can form plaque in the arteries, a ...

Viking is also developing VK2809, a novel, orally available, small molecule selective thyroid hormone receptor ... the treatment of non-alcoholic fatty liver disease (NAFLD) and elevated LDL ...