The hypothesis that it disrupts the function of retinal ganglion cell axons by increasing mechanical forces on the lamina cribrosa of the optic nerve head has received considerable experimental ...

Using an ingenious system of his own design, Downs had created the first high-resolution computer model of the lamina cribrosa, a mesh-like structure at the back of the eye that allows the optic nerve ...

However, optic nerve regeneration and restoration ... damage occurs due to a cascade of events that originates at the lamina cribrosa (Figure 1C) and can reach as far as the visual cortex.

Image: Anthony DeFino Berdahl noted that while IOP impacts the optic nerve ... transport stops or slows at the level of [the] lamina cribrosa, and the metabolic means of those individual ganglion ...