In mice with Leigh Syndrome—the most common childhood mitochondrial disease—the HypoxyStat drug extended lifespan by more than three-fold and reversed brain damage and muscle weakness ...

A number of clinical syndromes are currently believed to be associated with mitochondrial disease. Possible examples include Pearson syndrome, Leigh syndrome, progressive external ophthalmoplegia ...

The mitochondrial oxidative phosphorylation ... most of which have lost at least one child to encephalomyopathies, such as Leigh syndrome. Prenatal diagnosis is only rarely possible for mtDNA ...