In animal models, inhibition of neutrophil chemokines or disruption of these chemokine gradients in the lung attenuates ALI. Molecules associated with enhanced wound closure, such as epithelial ...

The researchers injected lung-targeted SORT LNPs intravenously to healthy mice engineered ... They identified a variety of cell types, including epithelial cells, immune cells, and stem cells. These ...

Because these cells can differentiate into various epithelial cell types, effective CFTR repair in basal cells could potentially lead to long-term improvements in lung function. By treating a ...

epithelial cell death and activation of proinflammatory pathways, which gives rise to the clinical entity known as ventilator-induced lung injury (VILI).