In the inactive conformation, the a-subunit of the G protein binds to GDP and is bound to a beta-gamma complex (a). Upon receptor activation by its ligand, there is an exchange of GDP for GTP (b).

Integral membrane proteins such as receptors and ion channels span the membrane. Peripheral membrane proteins, for example some signalling proteins, are tethered by an anchor, via a fatty acid ...

GPCRs are integral membrane proteins that span the entire lipid bilayer and are involved in many critical processes, such as responding to adrenaline or other signals. These proteins are also the ...

A research team from the Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences, along ...

Nuclera, the biotechnology company accelerating protein expression and optimization through its benchtop eProtein Discovery™ system, today announced the addition of a new membrane protein workflow to ...

Most drugs target membrane proteins, accessible on the surface of cells ... The Diver lab’s approach is comprehensive, spanning tissues to cells to high-resolution structures, and exploits a range of ...

Proteins interacting with cell membranes play a vital role in countless biological processes, from how cells communicate to how they respond to external signals like hormones or medications.