Mitochondria, often seen as cellular powerhouses, play a surprising role in immune regulation. Researchers found that ...

Precursor proteins are unfolded and imported into mitochondria by a macromolecular machine that spans two membranes and contains at least nine different proteins. Here we examine import of a model ...

Scientists in the laboratory of Navdeep Chandel, Ph.D., the David W. Cugell, MD, Professor of Medicine in the Division of ...

A new study uncovers a novel mechanism through which brown fat is transformed into heat, offering protection against ...

Researchers have identified a mechanism where the removal of the mitochondrial protein MCJ in mice leads to increased heat ...

Mitochondria organelles came from primordial bacterial endosymbionts and still preserve distinct genes for important functions like making ATP. To speed the emerging therapeutic research into the ...

Researchers found that bioengineered CAR-T cells when mixed with other immune cells can "donate" proteins, suggesting ...

There are several mechanisms involved. The newly reported research has uncovered one mechanism, which they found is controlled by the mitochondrial protein MCJ. The researchers first identified ...

Researchers revealed mitochondria's role in immune regulation through IL-10 production, controlled by mitochondrial complex ...

A novel mechanism that enables cells to maintain energy production even when their main power supply drops/fails has been ...

Mitochondria are critical for cellular homeostasis, regulating bioenergetics, redox balance, Ca2+ signaling, and cell death.

A thermal stability-based proteomic analysis identifies cytoplasmic PEBP1 as a mediator of mitochondrial dysfunction-induced stress response, highlighting its potential role in cellular adaptation ...