1% of mitochondrial proteins are encoded by the mitochondrial genome and synthesized in the mitochondrial matrix. The translocase of the outer membrane (TOM) complex is the main entry gate used by ...

Mitochondria, often seen as cellular powerhouses, play a surprising role in immune regulation. Researchers found that ...

For 1.5 billion years, the mitochondrial ... maintain coadapted gene complexes. Researchers are now coming to appreciate that this has consequences for physiology and even macroevolution. Researchers ...

A novel mechanism that enables cells to maintain energy production even when their main power supply drops/fails has been uncovered by biologists at Duke-NUS Medical School. In collaboration with an ...

Cyanobacteria began contributing oxygen to Earth's mostly noxious atmosphere more than 2 billion years ago. The photosystem ...

While significant progress has been made in understanding the protein components of mitochondrial complexes, the role of certain conserved proteins remains enigmatic. Initially identified in ...

We study the molecular mechanism of proteins involved in biological energy conversion and mitochondrial function/dysfunction (respiratory complexes I-V). We apply multi-scale computational approaches ...

The study shows that mitochondria do more than provide energy; they play an active role in modulating the immune response.

Cancer cells cripple immune cells by donating their damaged mitochondria, hindering the immune response and fostering tumour ...

However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...