the exact mechanism by which mutant huntingtin causes neuronal dysfunction is not known. Recent studies demonstrating altered messenger RNA expression point to transcriptional dysregulation as a ...

A new discovery offers hope for Huntington’s disease. This discovery provides hope that a DNA repair process may help slow or ...

For instance, a new small molecule called branaplam has shown promise in reducing mutant huntingtin levels by promoting ... (ASOs): Short strands of DNA or RNA that can bind to specific RNA ...

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease ...

For years the lab has been conducting basic research into the Spt5 regulatory protein, a large protein with many functional segments that helps in the production of messenger RNA molecules and is ...

HD is caused by an expanded glutamine repeat in the N-terminal region of the huntingtin (HTT) protein ... High expression of the mutant HTT is significantly correlated with the downregulation of the ...