For all six proteins, three 'loop' regions are most important for sequence specific DNA binding. The first of these is a segment between the first two strands of the Ig-fold, referred to as the A ...

For instance, to provide further proof that a protein-DNA binding interaction is unique, or specific to a particular sequence, researchers often perform a so-called competition assay. Such an ...

To do so, they planned to stabilize proteins at their chromatin binding locations and use nucleic acid hybridization to fish out specific ... found that hsp70 DNA of heat-shocked cells migrated faster ...

A gene is a fundamental unit of heredity, consisting of a specific ... in the DNA sequence. Methylation can lead to gene silencing by preventing transcription factors from binding to the promoter ...