These include famous genes such as K-ras and p53. One notable exception is the cyclin-dependent kinase inhibitor p27 Kip1. p27 is an inhibitor of the cell cycle, and thus a candidate tumor ...
Several pieces of evidence indicate that the tumour suppressor p27 (encoded by CDKN1B) has other functions beyond its role as a cell-cycle inhibitor. James Roberts, Arnaud Besson and colleagues ...
Recent work has discovered the role of the cyclin-dependent kinase (CDK)-binding protein Cks1 in degrading the CDK inhibitor p27 Kip1. This process is essential for DNA replication and is ...
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