p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

In humans and other multicellular organisms, cells multiply. This defining feature allows embryos to grow into adulthood, and ...

Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become ...

Scientists at Sanford Burnham Prebys and collaborators across the country published findings March 5, 2025, in Nature ...

Around this time, cancer researchers across different disciplines concluded that the gene encoding p53 was an oncogene. Once they started searching, scientists found p53 in almost every cancer type.

Loss of normal p53 function has been associated with resistance to both chemotherapy and radiotherapy. Introduction of wild-type (wt) p53 by means of adenoviral vectors has been shown to inhibit ...

A first-ever analysis of the whole Greenland shark genome gives researchers a couple of clues to their longevity.

A team from University Hospitals Seidman Cancer Center is launching the nation's first-ever clinical trials evaluating the ...

The ATM gene (mutated in the disease ataxia telangiectasia) activates the p53 tumor suppressor protein in response to DNA damage, explaining the higher incidence of cancer in AT patients.