There must be some way to specify which target genes of p53 are to be selected. The different serine phosphorylation sites in the p53 protein may be the 'sensors' that choose which target genes ...
p53 is a common denominator among human cancers. How was it discovered? What are the persistent questions about its function? Aa Aa Aa It seems nearly impossible for a normal cell to become a ...
The increase in MDM2 could be due to a high phosphorylation of the p53 N-terminal domain that prevents the formation of MDM2-p53 complexes with an accumulation of both molecules. Moreover ...
The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...