Idelasinib blocks one form of PI3K (delta), whereas duvelisib blocks two forms (delta and gamma). Because of new research into the potential safety risks of PI3K inhibitors, these therapies are ...

For MZL, the PI3K-delta and casein kinase CK1-epsilon inhibitor can be used in patients who have previously been treated with an antiCD20 drug like rituximab, while FL patients are only eligible ...

Pharming has submitted its oral phosphoinositide 3-kinase delta (PI3Kδ) inhibitor leniolisib for approval in the EU as a treatment for activated PI3K delta syndrome (APDS), an ultra-rare disease ...

Researchers from Tokyo University of Science uncover cellular and molecular mechanisms underlying the antidepressant-like effects of the delta opioid receptor agonists, paving the way for its ...

Despite these differences, the authors found that chemotaxis and electrotaxis share a dependence on similar intracellular signaling molecules, most notably the phosphoinositide 3-kinase (PI3K ...