The disorder usually affects just one or several bones, not the entire skeleton. The most common areas are the skull, legs, spine and pelvis. Symptoms of Paget’s disease include the fatigue and ...

Before the discovery of agents that specifically inhibited osteoclastic bone resorption, there was no effective treatment for Paget's disease. This situation changed with the development for ...

The disease usually affects just one or a few bones. The bones most commonly affected by Paget’s disease include the pelvis, skull, spine, femur and tibia. Many people with Paget’s disease do ...

The disease seems to occur in one of two patterns: monostotic (localized) and polyostotic (generalized). In humans, the most commonly affected bones are the pelvis, skull, femur, spine ...

Intensive bisphosphonate treatment does not confer a clinical advantage over treatment of symptoms alone in patients with Paget disease of bone. Findings from a UK study reveal that maintenance of ...

Ipriflavone can block part of the process that leads to bone loss. A bone disease that can cause pain (Paget disease). Early research shows that taking ipriflavone might decrease bone pain in some ...

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

Dear Doctors: I was recently diagnosed with Paget’s disease after suffering fatigue symptoms and muscle soreness in my neck, pelvic and lower-leg areas. I am sore and lethargic upon waking up in ...