Before the discovery of agents that specifically inhibited osteoclastic bone resorption, there was no effective treatment for ... unexpectedly, patients with more extensive disease tend to relapse ...

Dear Reader: The full name of the condition you have been diagnosed with is Paget’s disease of bone. Also known as osteitis deformans, it is a chronic bone disorder. When someone has Paget’s ...

Intensive bisphosphonate treatment does not confer a clinical advantage over treatment of symptoms alone in patients with Paget disease of bone. Findings from a UK study reveal that maintenance of ...

designed to compare the effects of intensive bisphosphonate therapy and symptomatic management in 1,324 patients with established Paget disease of bone (PDB) who were followed for a median of 3 years.

Ipriflavone can block part of the process that leads to bone loss. A bone disease that can cause pain (Paget disease). Early research shows that taking ipriflavone might decrease bone pain in some ...

Consider treating for more than 2 years only if patient remains at or ... metabolic bone diseases other than osteoporosis including Paget's disease of bone, bone metastases, history of skeletal ...

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

Dear Doctors: I was recently diagnosed with Paget’s disease after suffering fatigue symptoms and muscle soreness in my neck, pelvic and lower-leg areas. I am sore and lethargic upon waking up in ...