Melbourne-based researchers at the Walter and Eliza Hall Institute (WEHI) at the Parkinson's Disease Research Centre have ...

Undiscovered cause of Parkinson’s found for first time by scientists in huge breakthrough - Experts make breakthrough that ...

Despite being a mainstay of Parkinson's disease treatment, levodopa, a dopamine-replenishing medication, can cause nasty side-effects with long-term use. A recent human trial found that a new drug ...

A team from the Wistar Institute has demonstrated the role of Parkin—a protein implicated in Parkinson's disease—in the body's innate immune response to cancer. Parkin is not expressed in ...

This new cryo-EM structure represents a remarkable advance in our understanding of how human PINK1 is stabilized” said ...

Discover PINK1 structure offers new hope for Parkinson’s disease treatment by revealing its mitochondrial interactions and ...

A recently launched Phase 1 clinical trial is examining the safety and feasibility of a groundbreaking treatment approach for Parkinson's disease in which a patient's stem cells are reprogrammed ...

Notably, mutations in human Parkin or PINK1 are the most common causes of a type of early-onset Parkinson’s disease 7. To investigate further, Yamada et al. generated mice lacking OMA1 and ...

Johns Hopkins University School of Medicine researchers have discovered a dual regulatory mechanism safeguarding mitochondrial integrity through the combined actions of Parkin–PINK1 and OMA1.

As a leading neurodegenerative disorder, Parkinson's disease is characterized by the ... Furthermore, TFE3 activation restores the function of Parkin, a protein essential for mitophagy, the ...