Owing to the short half-life of PINK1, we showed the PINK1-Parkin pathway is particularly sensitive to translational inhibition. The intracellular levels of ATP correlate with changes in PINK1 and ...

Ubiquitin is a small, covalent modifier that forms a poly-ubiquitin chain on protein, which becomes a degradation signal attacked by the 26S proteasome 11,12,13. The poly-ubiquitin chain is ...

Are there key genes involved in TKI resistance in ccRCC? What mechanisms are associated with this development? A research team, led by Professor Ben Liu from the Department of Urology at the First ...

A report published in PLoS Biology provides evidence that PTEN-induced putative kinase 1 (PINK1) is involved in selective autophagy of dysfunctional mitochondria. Recessive mutations in the PINK1 ...