Tangentially, other biophysicists tried to figure out their own early version of the patch clamp method. David Clapham, now a biophysicist at the Howard Hughes Medical Institute, became fascinated ...

Currently the only method for measuring ion channel activity is the patch-clamp method, in which a cell's membrane is pierced by the tip of an electrode-containing micropipette. The electrode detects ...

The method is not only of relevance for neuromedicine ... diameter at the channel and recording changes in electrical current ...

Both the newcomer and the experienced user of patch clamp programs will feel comfortable ... for star ground connections, the proven method to avoid ground loops in any electrophysiology setup.