THE peritoneal membrane ... pressure gradient across the peritoneum is greater. By contrast, when hypertonic saline solutions are instilled into the peritoneal cavity, intraperitoneal fluid ...

Drug delivery systems can alter drug clearance from the peritoneal cavity and drug toxicity profiles. For example, IP injection of cisplatin-loaded polymeric microspheres (100–200 µm ...

Peritoneal Carcinomatosis: A condition where cancer cells spread to the peritoneum, the lining of the abdominal cavity. Consensus Molecular Subtype 4 (CMS4): A classification of colorectal cancer ...

Based on the aforementioned PK/PD considerations, we elected a particle size of 4–6 µm to retard the lymphatic clearance and to promote distribution within the peritoneal cavity. TPMs have ...