A single administration of the epigenetic modifiers achieved efficient and durable silencing of the Pcsk9 gene in mice, almost halving circulating levels of the PCSK9 protein, for up to 330 days ...

Argonaute proteins associate with small non-coding RNAs (such as small interfering (si)RNAs and microRNAs (miRNAs)) and function in RNA-based silencing mechanisms by altering protein synthesis and ...

A new discovery offers hope for Huntington’s disease. This discovery provides hope that a DNA repair process may help slow or ...

This resistance often emerges in metastatic tumours, because cancer cells can evolve in ways that allow them to survive, such ...

Researchers developed an epigenetic editing approach to silence the PCSK9 gene, achieving long-term cholesterol reduction ...

This promiscuous binding activity means that miRNA can act on many different mRNAs, potentially silencing hundreds of genes simultaneously. In contrast, when RNAi is guided by siRNA, the entire ...

This DNA-binding protein was previously known to have played ... This newly discovered mechanism offers a fresh insight into long-range gene silencing in bacteria. This is the phenomenon by ...

2003). In a collaborative study championed by the Nam-Hai Chua lab (Rockefeller University), it was demonstrated that that the Cucumber mosaic virus-encoded 2b protein blocks Ago1 cleavage activity to ...

This DNA-binding protein was previously known to have played ... This newly discovered mechanism offers a fresh insight into long-range gene silencing in bacteria. This is the phenomenon by ...