Recently, spironolactone has been recommended to attenuate some of the neurohormonal effects of heart failure. The Randomized Aldactone Evaluation Study (RALES) was designed to determine the ...

Physical examination findings include inflamed joints, subcutaneous nodules, a pericardial friction rub, findings of congestive heart failure (edema, pulmonary rales, elevated jugular venous ...

Researchers at the University of Toronto's Institute of Biomedical Engineering have found that studying blood flow in leg ...

Chronic heart failure is a syndrome ... Spironolactone was investigated in the Randomized Aldactone Evaluation Study (RALES) trial, and a mortality benefit was shown in patients categorized ...

The landmark Randomized Aldactone Evaluation Study (RALES), published in 1999, showed that spironolactone, a potassium-sparing diuretic, improves outcomes in patients with severe heart failure.

Summary: Heart failure is a clinical syndrome characterized by the functional inability of the ventricle to meet the metabolic demands of the body. Renal hypoperfusion occurs as a result of ...

Rales were present at both lung bases ... A 64-year-old man gave a history of progressive heart failure of 3 years' duration. He had been known to have hypertension and coronary-artery disease ...