Cells have proteins called receptors ... tyrosine are especially common sites for phosphorylation. These phosphorylation reactions control the activity of many enzymes involved in intracellular ...

The ERBB receptors are a ... they form the most potent signaling pair in terms of mitogenic signaling (signals that cause cell division) (Table 1). Table 1: Kinase Activity and Ligand Binding ...

Investigators conducted a retrospective review that spanned 10 years with the goals of describing the clinical ...

TIE1, a receptor tyrosine kinase, was found to be upregulated by ... In conclusion, this work has identified a novel signaling pathway involving ING5, TIE1, and PDK1 Y163 phosphorylation that ...

Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...

Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways. Over 10,000 patients have ...

The FDA has granted Priority Review to nipocalimab for the treatment of antibody positive patients with generalized myasthenia gravis.