To do this, researchers used prime editing to insert a recognition sequence into the genomes of the human cell lines to target with recombinase—an enzyme that enabled the team to 'shuffle' the ...

The new method uses a combination of prime editing, which can directly make a wide range of edits up to about 100 or 200 base pairs, and newly developed recombinase enzymes that efficiently insert ...

A team of researchers from the Arc Institute have discovered the bridge recombinase mechanism, a precise and powerful tool to recombine and rearrange DNA in a programmable way. Going far beyond ...

His research is based on the Cre-Lox system which exploits the ability of a recombinase enzyme called Cre to delete genes flanked by pieces of bacteriophage DNA called loxP. The Cre-lox system can ...

Recombinase polymerase amplification (RPA) is a technique for rapidly copying segments of DNA. Unlike polymerase chain reaction (PCR), it does not require thermal cycling, so less equipment is needed.

Recombinase-based methods allow scientists to move pieces of DNA from plasmid to plasmid without restriction enzymes, simplifying and expediting the cloning process. It also prevents the aggravation ...

In repair, the DSB is resected to produce ssDNA, which is then coated by RecA/Rad51 to produce a presynaptic nucleoprotein filament, essentially the substrate-bound form of the recombinase enzyme ...

a genetics medicines company leveraging new technology that allows them to edit the genes in a wide range of cells with the enzyme recombinase. Seymour explains how the company’s unique platform ...