The potential target, the FLT1 gene, contributes to the production of a protein, fetal hemoglobin, whose presence is already ...

A gene known as HbS was the center of a medical and evolutionary detective story that began in the middle 1940s in Africa. Doctors noticed that patients who had sickle cell anemia, a serious ...

However, the role of hemoglobin in the understanding of genetic disease has been equally powerful. Over 300 abnormal hemoglobins — such as sickle cell hemoglobin — have been discovered ...

A 21-year-old man has become the first person in New York—and one of the first in the world—to be cured of sickle cell anemia. A novel form of gene therapy enabled the man to receive a life-changing ...

How do mutations happen, and how do they influence the future of a species? Molecules of sickle-cell hemoglobin stick to one another, forming rigid rods. These rods cause a person's red blood ...

Scientists have discovered more than a dozen genes that regulate the production of fetal hemoglobin in people of African ...

Sebastien Beauzile became the first person in NY to be made symptom-free after undergoing a new type of gene therapy.

Sickle cell hemoglobin (HbS) behaves like normal hemoglobin when fully oxygenated, but at low oxygen tension the hydrophobic valine residues cause the HbS to polymerize, resulting in gel formation ...

“Now he’s producing normal adult hemoglobin in his parent cells. You see it in his blood as well,” Dr. Aygun said. “That’s why he’s not having any symptoms related to his sickle cell ...

Sickle cell disease (SCD) is a genetic disorder of the red blood cells caused by a mutation in the HBB gene. This gene encodes a protein that is a key component of hemoglobin, a protein complex ...